Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-02
1999-07-27
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514400, 514 34, 514274, 424649, A61K 31415, A61K 3170, A61K 31505, A61K 3324
Patent
active
059291044
ABSTRACT:
Disclosed herein are a method for inducing apoptosis of cancer cells, which comprises administering an effective amount of a 2-nitroimidazole derivative represented by the general formula (1): ##STR1## wherein R represents an alkyl, alkenyl or alkynyl group substituted by 1 to 3 hydroxyl groups, and a method for treating a cancer, which comprises using the method for inducing apoptosis in combination with another means for killing cancer cells.
REFERENCES:
Seg-Lasley et al., Manual of Oncology Therapeutics, C.V. Mosby Co., St Louis pages 88&104, 1981.
Sakakura et al., Int. J. Cancer, 67, 101-105 (1996).
Adams et al., Radiation Research, 67, 9-20 (1976).
Phillips et al., Cancer, 48, 1697-1704 (1981).
Saito et al., Report of the 9th Annual Meeting of The Japanesse Society foor Therapeutic Radiation and Oncology (Jastro), with translation.
Furusawa Yoshiya
Kamohara Atsuko
Ohyama Harumi
Saito Mizuho
Yamada Takeshi
Goldberg Jerome D.
Pola Chemical Industries Inc.
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