Method for inducing a systemic immune response to an antigen

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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4241841, 4241931, 42419611, 42419711, 4242041, 436829, A61K 9127, A61K 9133

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active

060155760

ABSTRACT:
A method is provided for inducing a systemic immune response to an antigen in a mammal. The method comprises orally administering lyophilized multilamellar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.

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