Chemistry: analytical and immunological testing – Including chromatography
Patent
1986-03-31
1988-03-29
Lacey, David L.
Chemistry: analytical and immunological testing
Including chromatography
73 611C, G01N 3006
Patent
active
047343770
ABSTRACT:
Method for indirect detection of transparent compounds in liquid chromatography through their interaction with a detectable additive present at saturation in the system. One embodiment of the invention includes a liquid chromatographic column, a detector and an eluent which contains an additive at saturation. The detector is tuned to a property of the additive. When an analyte that cannot be directly detected by the detector is injected, it interacts with the additive either by solubilizing it, or by displacing it from the stationary phase. When the analyte enters the detector it is indirectly detected by the induced change in concentration of the additive.
REFERENCES:
Sujit Banerjee et al., Indirect Detection of Non-Electrolytes in Liquid Chromatography with Additive Saturated Elements, Journal of Chromatography, 396 (1987) pp. 169-175.
Sujit Banerjee, General Indirect Detection of Nonelectrolytes in Liquid Chromatography by Solubility Enhancement, Analytical Chemistry, vol. 57, No. 13, Nov. 1985, pp. 2590-2592.
Sujit Banerjee, Solubility of Organic Mixtures in Water, Environmental Science & Technol, vol. 18, No. 8, Aug. 1984, pp. 581-591.
Banerjee et al., General Indirect Detection of Nonelectrolytes in Liquid Chromatography, Abstracts, Pittsburgh Conf. (1986), No. 376, p. 376.
Parkin, Journal of Chromatography, 287 (1984) 457-461.
Cortes et al., Journal of Chromatography, 295 (1984) 269-275.
Parkin et al., Journal of Chromatography, 314 (1984) 488-494.
Parkin, Journal of Chromatography, 303 (1984) 436-439.
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