Method for increasing tumor sensitivity to chemotherapy

Details Method for increasing tumor sensitivity to chemotherapy Method for increasing tumor sensitivity to chemotherapy

1989-10-13

1991-04-09

Pellegrino, Stephen C.

Surgery

Body protecting or restraining devices for patients or infants

Restrainers and immobilizers

604 20, 604 52, 514557, A61N 100

Patent

active

050055887

ABSTRACT:
Drug-resistant tumor cells are rendered drug-sensitive by administering to the tumor cells a pump-affecting compound which suppresses the pumping action of P-glycoprotein on the tumor cells. In the case where the tumor cells have higher .beta.-glucuronidase activity than that of the surrounding tissues, the pump-affecting compound is in the form of a .beta.-D-glucuronide.

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patent: 4490523 (1984-12-01), Rubin et al.
Hurwitz, D., "Attempts at Site-Directed Experimental Chemotherapy with Antibody Drug-Conjugates," Optimization of Drug Delivery, Alfred Benzon Symposium 17. Editors: Hans Bundgaard, Anne Bagger Hansen, Helmer Kofod, Munksgaard, Copenhagen 1982.
Kartner, N. and Ling, V., "Multidrug Resistance in Cancer," Sci. Amer., Mar. 199, pp. 44-51.
Juranka et al., "P-Glycoprotein: Multidrug-resistance and a superfamily of membrane associated transport proteins," FAS, Dec. 1989 3(14) pp. 2583-2592.

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