Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1998-09-25
2000-09-05
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
43525233, 4352528, 435949, C12P 742, C12N 120
Patent
active
061141577
ABSTRACT:
This invention pertains to a method of production of 4-hydroxybenzoic acid, with purification and recovery of 4-hydroxybenzoic acid directly from the fermentation medium of a cultured organism, in the presence of other chemical species. Ion exchange resin is used during the fermentation process to recover the chemical product without the necessity of separating the biomass from the fermentation supernatant by filtration after fermentation is complete and then treating the filtrate to recover the product. This reduces or eliminates the need for filtration steps and eliminates the need for energy-intensive water removal processes. Furthermore, the removal of the product during the fermentation dramatically increases the production of the product during the fermentation process. This method therefore can both increase the amount of product produced in a single fermentation run and reduce the per unit cost of its biocatalytic production.
REFERENCES:
patent: 4851573 (1989-07-01), Kulprathipanja et al.
W. Crueger and A. Crueger, Biotechnology: A Textbook of Industrial Microbiology, Sinauer Associates, Sunderland, MA, pp. 124-174 (1990).
B. Atkinson and F. Mavituna, Biochemical Engineering and Biotechnology Handbook, second edition, Stockton Press, NY, pp. 243-364 (1991).
A. Berry, Tibtech 14:250-256 (1996).
P. Vonktaveesuk et al., J. Ferment. Technol. 77:508-512 (1994).
Y. Nomura et al., J. Ferment. Technol. 71:450-452 (1991).
V. Yabannavar and D. Wang, Biotechnol. Bioeng. 37:1095-1100 (1991).
S. Zhang and K. Toda, J. Ferment. Technol. 77:288-292 (1994).
B. Atkinson and F. Mavituna, Biochemical Engineering and Biotechnology Handbook, second edition, Stockton Press, NY, pp. 905-1022 (1991).
Amaratunga Mohan
Johnson Bruce Fletcher
Lobos John Henry
Crosby Mike W.
General Electric Company
Johnson Noreen C.
Lilling Herbert J.
LandOfFree
Method for increasing total production of 4-hydroxybenzoic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for increasing total production of 4-hydroxybenzoic acid , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for increasing total production of 4-hydroxybenzoic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2211174