Method for increasing the yield of antibodies in the techniques

Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific...

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4241841, 514494, 514499, 514885, 5303881, 5303891, A61K 4500, A61K 3900, A61K 3130, A61K 31315

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active

060045647

ABSTRACT:
The new method uses synthetic glycopeptides such as MDP and GMDP as immunological adjuvants which according to this invention are added to the antigen in purely aqueous solution in the low doses discovered to evoke the maximum production of antibody output and whereby the adjuvant is present in dry form with L-proline added for better reproducibility of experiments by minimizing adsorptive losses at the walls of the glass vials.

REFERENCES:
B. Bennett, et al (1992) "A comparison of commercially available adjuvants for use in research", in: Journal of Immunological Methods, vol. 153, pp. 31-40.
R. Bomford, et al (1992) "The Control of the Antibody Isotype Response to Recombinant Human Immunodeficiency Virus gp120 Antigen by Adjuvants", in : AIDS Research and Human Retroviruses, vol. 8, pp. 1765-1771.
F. Ellouz, et al (1974) "Minimal Structural Requirements for Adjuvant Activity of Bacterial Peptidogylcan Derivatives", in: Biochemical and Biophysical Research Communications, vol. 59, No. 4, pp. 1317-1325.
J. Freund, et al (1948) "Antibody Formation and Sensitization with the Aid of Adjuvants", in: J. Immunology, vol. 60, pp. 383-398.
T. Andronova, et al (1991) "The Structure and Immunomodulating Function of Glucosaminylmuramyl Peptides", in: Sov. Medical Reviews D Immunology, vol. 4, pp. 1-63.
Jules Freund, "The Mode of Action of Immunologic Adjuvants", in: Advances Tuberculosis Research, vol. 7, (1956) pp. 130-148.
H. Shaw Warren, et al, "Future Prospects for Vaccine Adjuvants", in: CRC Critical Reviews in Immunology, vol. 8, Issue 2 (1988), pp. 83-101.
Robert L. Hunter, et al, "The Adjuvant Activity of Nonionic Block Polymer Surfactants", in: The Journal of Immunology, vol 133, No. 6, Dec. 1984, pp. 3167-3175.
Anthony C. Allison, et al, "An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity", in: Journal of Immunological Methods, vol. 95 (1986), pp. 157-168.
S. Kotani, et al, (1975) Biken J., vol. 18, pp. 105-111. Applicant does not presently have and has been unable to locate a copy of this reference; hence, no copy thereof is attached.
Masachika Tsujimoto, et al, "Adjuvant Activity of 6-0-Acyl-Muramyldipeptides to Enhance the Primary Cellular and Humoral Immune Responses in Guinea Pigs: Adaptability to Various Vehicles and Pyrogenicity", in: Infection and Immunity, Sep. 1986, pp. 511-516.
Noelene E. Byars, et al, "Adjuvant forumulation for use in vaccines to elicit both cell-mediated and humoral immunity", in: Vaccine, vol. 5, Sep. 1987, pp. 223-228.
Frederick R. Vogel, "A Compendium of Vaccine Adjuvants and Excipients", in: Vaccine Design, Pharmaceutical Biotechnology Series, Plenum Publishing Corporation, New York, NY (1994).
R. Bomford, "Adjuvants for Viral Vaccines", in: Reviews in Medical Virology, vol. 2, 1992, pp. 169-174.
Domkus et al. 1995 5.sup.th Int. Congress on Anti-Cancer Chemotherapy Poster P517.
Arakawa et al 1993. Adv. Drug Delivery Rev. 10:1-28.
Ramasamy et al. 1993. J. Natn. Sci. Council Sri Lanka 21(1):125-140.
Bahr et al 1983. Mol. Immunology 20(7):745-752.
Hosdorf et al 1935. J Immunologuy 29:389-425.
Nesmeyanov et al. 1990. Biomedical Sci. 1(2):151-154.
Shapira et al. 1985. Int. J. Immunopharmco. 7(5):719-723.
Grubhofer et al. 1994 FASEB Journal 8(4-5):A993.
Gregoriadis et al. 1989 Immunol Letters 20:237-240.
Shimizu et al 1992. Int. J. Immunopharmac. 14(8):1415-20.
Michalek et al 1983. Molecular Immunol 20(9):1009-18.
Sharma et al. 1988. Technol. Adv. Vaccine Dev. 107-116.
Nash et al. 1985., J. Reprod. Immunol. 7:151-162.
Abehsira-Amar et al 1987. Mol. Immunol. 24(9):945-51.
Hilgers et al 1992. Res. Immunol. 143:494.
Isujimoto et al. 1986, Inf. & Imm. 53(3):511-516.
Allison et al 1988, Technol. Adv. Vaccine Dev. 401-409.
Mozes et al. 1980, PNAS 77(8):4933-4937.
Leclerc et al 1978, Immunology 35:963-970.
Lewy et al. 1980, Immunology 39:441-450.
Alam et al. 1991, Immunol. Letters 27:53-58.
Yin et al 1989, J. Biol. Response Modifiers 8:190-205.
Zhonghua Weishengwuxue He Mianyixue Zazhi Lu et al. 3(5):300-304 Abstract only, 1983.
Parant et al. Infection 13(Suppl 2):S251-S255, 1985.

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