Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1993-07-13
1997-04-08
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424 931, 435174, 435176, 435177, 435180, 435325, A01N 6300, C12N 1100, C12N 1114, C12N 1102, C12N 1108, C12N 500
Patent
active
056185316
ABSTRACT:
A method for increasing the viability of viable cells which are administered to the brain or spinal cord of a mammalian subject. This method is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain or spinal cord. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 .mu.m. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.
REFERENCES:
patent: 3974526 (1976-08-01), Darik et al.
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4505266 (1985-03-01), Yannas et al.
patent: 4520821 (1985-06-01), Schmidt et al.
patent: 4553272 (1985-11-01), Mears
patent: 4576608 (1986-03-01), Homsy
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4645669 (1987-02-01), Reid
patent: 4721096 (1988-01-01), Naughton et al.
patent: 4748121 (1988-05-01), Beaver et al.
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 4900553 (1990-02-01), Silver et al.
patent: 4902288 (1990-02-01), Ingram
patent: 4963489 (1990-10-01), Naughton et al.
patent: 5008116 (1991-04-01), Cahn
patent: 5032508 (1991-07-01), Naugton et al.
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5082670 (1992-01-01), Gage et al.
patent: 5160490 (1992-11-01), Naughton et al.
patent: 5202120 (1993-04-01), Silver et al.
Aebischer et al., 1988, "Transplanation of neural tissue in polymer capsules," Brain Research 448:364-368.
Aebischer et al., 1991, "Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line," Exp. Neorol. 111:269-275.
Anderson et al., 1989, "Gene expression in implanted rat hepatocytes following retroviral-mediated gene transfer," Somat. Cell Mol. Genet. 15:215-227.
Arnaout et al., 1989, "Intraperitoneal transplantation of microcarrier-attached enterocytes in rats," Am. J. Surg. 157:89-92.
Arnaout et al., 1990, "Development of bioartificial liver: Bilirubin conjugation in gunn rats," J. Surg. Res. 48:379-382.
Backlund et al., "Toward a transplantation therapy in Parkinson's disease," Ann. NY Acad. Sci. 658-673(1987).
Bankiewicz et al., 1987, "Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary allografts," Prog. Brain Res. 78:543-549.
Bazeed et al., 1983, "New treatment for urethral strictures," Urol. XXI:53-57.
Bazeed et al., 1983, "New surgical procedure for management of peyronie disease," Urol. XXI:501-504.
Bell et al., 1981, "Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness," Science 211:1052-1054.
Bell et al., 1983, "The reconstitution of living skin," J. Invest. Dermatol. 81:2s-10s.
Breakefield, 1988, "Retroviral gene transfer of beta-nerve growth factor into cultured cells," J. Cell. Biochem., Suppl. 12(Part B):170, Abstract H102.
Burke et al., 1984, "The effects of configuration of an artificial extracellular matrix on the development of a functional dermis," The Role of Extracellular Matrix in Development, pp. 351-355.
Buzaki et al., 1987, "Behavioral dependence of the electrical activity of intracerebrally transplanted fetal hippocampus," 400:321-333.
Chen et al., 1991, "Cellular replacement therapy for neurologic disorders: Potential of genetically engineered cells," J. Cell. Biochem. 45:252-257.
Collier et al., "Norepinephrine deficiency and behavioral senescence in aged rats," Ann. NY Acad. Sci. 396-403 (1987).
Columbo et al., 1987, "In vitro culture and labeling of neural cell aggregates followed by transplantation," Exp. Neurol. 98:606-615.
Cowan et al., 1986, "Similar biochemical associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats," Proc. Natl. Acad. Sci. USA 83:9328-9332.
Davis et al., 1987, "Human amnion membrane serves as a substratum for growing axons in vitro and in vivo," Science 236:1106-1109.
Demetriou et al., 1986, "New method of hepatocyte transplantation and extracorporeal liver support," Ann. Surg., 204:259-271.
Demetriou et al., 1986, "Survival, organization, and function of microcarrier-attached hepatocytes transplanted in rats," Proc. Natl. Acad. Sci. USA 83:7475-7479.
Demetriou et al., 1988, "Transplantation of microcarrier-attached hepatocytes into 90% partially hepatectomized rats," Hepatol. 8:1006-1009.
Demetriou et al., 1991, "Hepatocyte transplantation: A potential treatment for liver disease," Digest. Dis. Sci. 36:1320-1326.
Faktorovich et al., 1990, "Photoreceptor rescue in the RCS rat: Effect of bFGF, aFGF, and selected controls," IOVS Suppl. 31:595, Abstract. No. 2917-15.
Felcher et al., 1987, "Wound healing in normal analbuminemic (NAR) rats," J. Surg. Res. 43:546-549.
Fiandaca et al., 1988, "Adrenal medullary autografts into the basal ganglia of cebus monkeys injury-induced regeneration," Experimental Neurology 102:76-91.
Foster et al., 1988, "Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe neurones after transplantation to the adult rat central nervous system," Exp. Brain Res. 70:225-241.
Freed et al., 1981, "Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior," Nature 292:351-352.
Gage et al., 1987, "Grafting genetically modified cells to the brain: Possibilities for the future," Neuroscience 23(3):795-807.
Gage et al., 1988, "Human amnion membrane matrix as a substratum for axonal regeneration in the central nervous system," Exp. Brain Res., 72:371-380.
Gallico et al., 1984, "Permanent coverage of large burn wounds with autologous cultured human epithelium," New Eng. J. Med. 311:448-451.
Gash et al., 1986, "Amitotic neuroblastoma cells used for neural implants in monkeys," Science 233:1420-1422.
Gelderd and Quarles, 1990, "A preliminary study of homotopic fetal cortical and spinal cotransplants in adult rats," Brain Res. Bullet. 25:35-48.
Harkness et al., 1984, "Effect of pituitary hollow fiber units and thyroid supplementation on growth in the little mouse (41949)," Proc. Soc. Exp. Biol. Med. 177:312-317.
Hatton et al., 1992, "Migration of grafted rat astrocytes: Dependence on source/target organ," GLIA 5:251-258.
Hymer et al., 1981, "Pituitary hollow fiber units in vivo and in vitro," Neuroendocrinol. 32:339-349.
Hymer et al., 1981, "Pituitary hollow fiber unirts in the dwarf mouse," Neuroendocrinol. 32:350-354.
Hymer et al., 1987, "Heterotransplantation of human prostatic tissue," The Prostate 10:95-114.
Jaeger et L., 1988, "Plasticity of astroglia: Evidence supporting process elongation by stretch <" GLIA 1:31-38.
Jaeger et al., 1990, "Polymer encapsulated dopaminergic cell lines as alternative neural grafts," Prog. Brain Res. 82:41-46.
Jaeger et al., 1991, "Repair of the blood-brain barrier following implantation of polymer capsules," Brain Res. 551:163-170.
Jaksic and Burke, 1987, "The use of artificial skin for burns," Ann. Rev. Med. 38:107-117.
Kilot et al., 1990, "Astrocyte-polymer implants promote regeneration of dorsal root fibers into the adult mammalian spinal cord," Exp. Neurol. 109:57-69.
Koller and Palsson, 1993, "Tissue engineering: Reconstituation of human hematopoiesis ex vivo," Biotech. Bioengineer. 42:909-930.
Kott et al., 1991, "Ultrastructural localization of gold particles within neural grafts labeled with gold-filled sendai viral envelopes," J. Microscopy Technique 18:197-202.
Langer and Vacanti, 1993, "Tissue Engineering," Science 260:920-925.
Lefkowitz et al., 1991, "Electrical properties of axons within Probst bundles of acallosal mice and callosi that have reformed upon glial-coated polymer implants,"
Dadio Susan M.
New York University
Wityshyn Michael G.
LandOfFree
Method for increasing the viability of cells which are administe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for increasing the viability of cells which are administe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for increasing the viability of cells which are administe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2396387