Method for increasing the solubility of clemastine and pharmaceu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3140

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active

057706182

ABSTRACT:
A method is disclosed for increasing the solubility of clemastine through the use of organic acid or its salts as a solubilizing agent. Particularly useful as solubilizing agents are salts of carboxylic acids, such as fumarate, maleate and citrate. Pharmaceutical compositions containing clemastine, and organic acids or its salts as solubilizing agents, are also disclosed.

REFERENCES:
patent: 4232002 (1980-11-01), Nogrady
patent: 4749700 (1988-06-01), Wenig
patent: 5192780 (1993-03-01), York et al.
"Clemastine Fumarate", American Hospital Formulary Service: Drug Information, 16-17 (1996).
"Clemastine Fumarate", American Hospital Formulary Service: Drug Information, 15-16 (1994).
"Clemastine Fumarate", Official Monographs of the United States Pharmacopeial Convention, Inc., 23, 385-386 (1995).
"Clemastine Fumarate", Martindale: The Extra Pharmacopoeia, 31, 438-439 (1996).
"Clemastine Fumarate", Remington's Pharmaceutical Sciences, 17, 1127 (1995).
USP DI, Drug Information for the Health Care Professtional, vol. 1, 13th ed., 1993.

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