Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-04-04
2006-04-04
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S324000, C530S345000, C530S402000, C530S405000, C530S409000, C530S410000, C530S421000, C435S069200, C435S180000, C435S181000, C435S215000, C424S193100
Reexamination Certificate
active
07022673
ABSTRACT:
A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human “uPA” or “hUPA”) or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
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Drummond Robert J.
Rosenberg Steve
Chiron Corporation
Harbin Alisa A.
Mohamed Abdel A.
Schneider Carol A.
Suh Young J.
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