Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-08-12
1997-10-14
Adams, Donald E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 72, 4352401, 4352402, G01N 33567
Patent
active
056771355
ABSTRACT:
Neural cells which express P75 nerve growth factor receptor (p75.sup.NTR) and which have a low resistance to .beta.-amyloid peptide toxicity are treated with a binding agent that binds with p75.sup.NTR. The resulting neural cells display an increased resistance to .beta.-amyloid peptide toxicity. Mutant and transfected neural cells are also disclosed in which the ability to express p75.sup.NTR has been removed with a resultant increase in resistance to .beta.-amyloid peptide toxicity.
REFERENCES:
Rabizadeh et al., "Induction of Apoptosis by the Low-Affinity NGF Receptor," Science, 16 Jul. 1993, vol. 261, pp. 345-348.
Tasadera et al., Neurosci. Lett., vol. 161, pp. 41-44, 1993.
Kozlowski et al., J. Neurosci., vol. 12, pp. 1679-1687, 1992.
Yansner et al., PNAS USA, vol. 87, pp. 9020-9023, 1990.
Mattson et al., Brain Res., vol. 621, pp. 35-49, 1993.
Adams Donald E.
Gucker Stephen
Reiter Stephen E.
University of California
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