Method for increasing the resistance of neural cells to .beta.-a

Details Method for increasing the resistance of neural cells to .beta.-a Method for increasing the resistance of neural cells to .beta.-a

1994-10-24

1996-11-19

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, 43524021, 514 2, 514 12, C12N 506, C12N 508, A61K 3818

Patent

active

055762093

ABSTRACT:
Neural cells which express P75 nerve growth factor receptor (p75.sup.NTR) and which have a low resistance to .beta.-amyloid peptide toxicity are treated with a binding agent that binds with p75.sup.NTR. The resulting neural cells display an increased resistance to .beta.-amyloid peptide toxicity. Mutant and transfected neural cells are also disclosed in which the ability to express p75.sup.NTR has been removed with a resultant increase in resistance to .beta.-amyloid peptide toxicity.

REFERENCES:
Rabizadeh et al., "Induction of Apoptosis by the Low-Affinity NGF Receptor," Science, 16 Jul. 1993, vol. 261, pp. 345-348.
Takadera et al., Neurosci. Lett., vol. 161, pp. 41-44, 1993.
Kozlowski et al, J. Neurosci., vol. 12, pp. 1679-1687, 1992.
Yankner et al., PNAS USA, vol. 87, pp. 9020-9023, 1990.
Mattson et al., Brain Res., vol. 621, pp. 35-49, 1993.

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