Method for increasing the permeability of the blood brain...

Details Method for increasing the permeability of the blood brain... Method for increasing the permeability of the blood brain...

2006-03-14

2006-03-14

Marschel, Ardin H. (Department: 1631)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07012061

ABSTRACT:
The present invention relates to a method for regulating the permeability of the blood brain barrier by administering a NOS-3 inhibitor to reduce the increased permeability of the blood brain barrier caused by a pathological condition or by administering a NOS-3 activator or nitric oxide donor to increase the permeability of the blood brain barrier. By increasing the permeability of the blood barrier, a therapeutic or diagnostic compound can be delivered across this barrier into the central nervous system.

REFERENCES:
patent: 5527527 (1996-06-01), Friden
patent: 5604198 (1997-02-01), Poduslo et al.
patent: 5648101 (1997-07-01), Tawashi
patent: 5670477 (1997-09-01), Poduslo et al.
Minami et al. “Roles of Nitric Oxide and prostaglandins in the Increased Permeabillity of the Blood-Brain Barrier Caused by Lipopolysaccharide”., Environmental Toxicology and Pharmacology. Jan. 1998, vol. 5, No. 1, pp. 35-41.
Barna et al. “Activation of Type III Nitric Oxide Synthase in Astrocytes Following a Neurotropic Viral Infection”, Virology, 1996, vol. 223, pp. 331-343.

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