Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-06-07
1999-08-10
Carlson, Karen Cochrane
Drug, bio-affecting and body treating compositions
Lymphokine
424 852, 574 2, 530350, 530351, A61K 4505, A61K 3700
Patent
active
059355654
ABSTRACT:
A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods in combination with other hematopoietic factors and a pharmaceutically acceptable carrier is provided as well as methods of treating patients which comprise administering to the patient the pharmaceutical composition of this invention. This invention provides combination therapies using c-kit ligand (KL) and a purified c-kit ligand (KL) polypeptide, or a soluble fragment thereof and other hematopoietic factors. It also provides methods and compositions for ex-vivo use of KL alone or in combination therapy. A mutated KL antagonist is also described. Such an antagonist may also be a small molecule. Antisense nucleic acids to KL as therapeutics are also described. Lastly, compositions and methods are described that take advantage of the role of KL in germ cells, mast cells and melanocytes.
Besmer Peter
Buck Jochen
Moore Malcolm A. S.
Nocka Karl
Carlson Karen Cochrane
Sloan-Kettering Institute for Cancer Research
White John P.
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