Method for increasing the efficacy of anti-tumor agents by...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S130100, C424S134100, C424S135100, C424S138100, C424S141100, C424S142100, C424S155100, C424S156100

Reexamination Certificate

active

07097836

ABSTRACT:
The present invention provides a method for enhancing the efficacy of chemotherapeutic agents for therapy of cancer and other angiogenesis-associated diseases such as rheumatoid arthritis. The method comprises the steps of administering to an individual in need of treatment, a combination of an anti-endoglin antibody and a chemotherapeutic agent. The anti-endoglin antibody and the chemotherapeutic agent may be administered sequentially or concurrently.

REFERENCES:
patent: 5660827 (1997-08-01), Thorpe et al.
patent: 6190660 (2001-02-01), Seon
Wiesenthal (http://weisenthal.org/feedback. html, Feb. 4, 2002).
Maier et al. (Anti-Cancer Drugs 1997; 8: 238-244).
Holmes (Seminars in Oncology 1996; 23: 46-56).
Seon (Int. J. Cancer 2002; 99: 310-311).
Takahashi et al. (Cancer Research 2001; 61: 7846-7854).
Biddle et al. (Leukemia Research 1989; 13: 699-707).
Buhring et al.Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow. Leukemia, 5: 841-847, 1991.
Burrows et al.Up-regulation of Endoglin on Vascular Endothelial Cells in Human Solid Tumors: Implications for Diagnosis and Therapy, Clin. Cancer Res., 1: 1623-1634, 1995.
Cheifetz et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J. Biol. Chem., 267: 19027-19030, 1992.
Fonsatti et al.Endoglin is a suitable target for efficieent imaging of solid tumors: In vivo evidence in a canine mammary carcinoma model. Clin. Cancer Res., 6: 2037-2043, 2000.
Gougos et al.Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line. J. Immunol., 141: 1925-1933, 1988.
Haruta et al.Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6. Proc. Natl. Acad. Sci. U S A, 83: 7898-7902, 1986.
Lastres et al.Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp- containing surface antigen.Eur. J. Immunol., 22: 393-397, 1992.
Li et al.Defective angiogenesis in mice lacking endoglin. Science, 284: 1534-1537, 1999.
Matsuzaki et al.Effect of Induced Transformation of Human Leukemia Cells on the Expression of GP160, A Novel Human Leukemia-Associated Cell Surface Glycoprotein, Fed. Proc. 46: 1056, 1987.
Matsuno et al.Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies. Clin. Cancer Res., 5: 371-382, 1999.
Miller et al.Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. Int. J. Cancer, 81: 568-572, 1999.
Rokhlin et al.Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. J. Immunol., 154: 4456-4465, 1995.
Seon et al.CD105 Workshop: Immunohistochemical detection of CD105 in the vascular endothelium of human malignant and non-malignant tissues. In: T. Kishimoto, H. Kikutani, A. E. G. Kr. Von dem Borne, S. Goyert, D.Mason, M. Miyasaka, L. Moretta, K. Okumura, S. Shaw, T. A. Springer, K. Sugamura, and H. Zola (eds.) Leukocyte Typing VI: White Cell Differentiation Antigens, pp. 709-710. New York: Garland Publishing, Inc., 1998.
Seon et al.Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clin. Cancer Res., 3: 1031-1044, 1997.
Tabata et al.Antiangiogenic radioimmunotherapy of human solid tumors in SCD mice using125I-labeled anti-endoglin monoclonal antibodies. Int. J. Cancer, 82: 737-742, 1999.
Wang et al.A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues. Int. J. Cancer, 54: 363-370, 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for increasing the efficacy of anti-tumor agents by... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for increasing the efficacy of anti-tumor agents by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for increasing the efficacy of anti-tumor agents by... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3626321

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.