Method for increasing shelf-life of a serum conjugated bilirubin

Details Method for increasing shelf-life of a serum conjugated bilirubin Method for increasing shelf-life of a serum conjugated bilirubin

1980-10-30

1982-08-17

Gron, Teddy S.

Compositions

Nonreactive analytical, testing, or indicating compositions

23230B, 23905, G01N 3348

Patent

active

043448640

ABSTRACT:
A stable blood serum conjugated bilirubin reference composition characterized in that the composition possess a pH of from about 8.2 to bout 9.2 and comprises (a) a sulfhydryl compound in an amount sufficient to enhance the stability of the conjugated bilirubin and (b) a chelating agent in an amount sufficient to bind all the metals present in the blood serum moiety of the composition. This blood serum conjugated bilirubin composition when stored in a gas impervious vial under an inert atmosphere has an excellent shelf life.

REFERENCES:
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patent: 4288343 (1981-09-01), Louderback
patent: 4311665 (1982-01-01), Wu
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Doumas, B. T., et al., Clin. Chem., vol 19, No. 9, pp. 984-993 (1973).
Louderback, A., et al., Fresenius Z. Anal. Chem., vol. 301, p. 145 (1980).

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