Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1988-11-14
1994-07-19
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514556, 514616, A61K 4900, A61K 31205, A61K 3116
Patent
active
053307445
ABSTRACT:
The present invention provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises treating the cells so as to render them resistant to an antitumor agent and contacting the resulting resistant cells under suitable conditions with an amount of a compound effective to selectively induce terminal differentiation of such cells. The compound has a structure:
REFERENCES:
patent: 4882346 (1989-11-01), Driscoll et al.
patent: 4935450 (1990-06-01), Cone
patent: 4961926 (1990-10-01), Gabrilove
patent: 4983636 (1991-01-01), Takeuchi
Chemical Abstracts: vol. 109(7) 47737e.
Breslow Ronald
Marks Paul A.
Pontremoli Sandro
Rifkind Richard A.
Criares T. J.
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia University in the City of New York
Waddell Frederick E.
White John P.
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