Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-01-01
2008-01-01
Mondesi, Robert B. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100
Reexamination Certificate
active
10473364
ABSTRACT:
This invention relates to a method for increasing the productivity of the secondary metabolite in a micro-organism, for example, the improvement of antibiotic producers by conferring drug-resistant mutations to micro-organisms.
REFERENCES:
patent: 4680260 (1987-07-01), Debabov et al.
patent: 5310677 (1994-05-01), Pollock et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 2 103 617 (1983-02-01), None
Yoshiko Hosoya et al. Antimicrobial Agents and Chemotherapy. 1998, vol. 42, No. 8, pp. 2041-2047.
J. Shima et al.: “Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance inStreptomyces lividansandStreptomyces coelicolorA3(2)” Journal of Bacteriology, vol. 178, No. 2, pp. 7276-7284, Dec. 1996.
A. Hesketh et al.: “A novel method for improvingStreptomyces coelicolorA3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin” The Journal of Antibiotics, vol. 50, No. 6, pp. 532-535, Jun. 1997.
Kozo Ochi et al.: “Genetic mapping and characterization of novel mutations which suppress the effect of a relC mutation on antibiotic production inStreptomyces coelicolorA3(2)” Journal of Antibiotics (Tokyo), vol. 51, No. 6, pp. 592-595, Jun. 1998.
J. Stastna et al.: “An antibiotic-overproducing mutant ofStreptomyces granaticolorwith impaired differentiation” Journal of Basic Microbilogy, vol. 27, No. 9, pp. 521-528, 1987.
Yoshiko Okamoto-Hosoya et al.: “Resistance to paromomycin is conferred by rpsL mutations, accompanied by an enhanced antibiotic production inStreptomyces coelicolorA3(2)” Journal of Antibiotics, vol. 53, No. 12, pp. 1424-1427, Dec. 2000.
H. Hu et al.: “Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations” Applied and Environmental Microbiology, vol. 67, No. 4, pp. 1885-1892, Apr. 2001.
Annu. Rev. Microbio., vol. 53, pp. 411-446 1999, Bentley et al.
PracticalStreptomycesGenetics, pp. 10-11 2000.
Actinomycetologica, vol. 5, pp. 86-99, (1991), Ikeda et al.
Protein, Nucleic Acid, Enzyme, vol. 44, No. 13, pp. 1967-1974 1999, (in Japanese).
Kagaku To Seibutsu, vol. 37, No. 11, pp. 731-737 1999, (in Japanese).
Y. Manjula Rao, et al., “Direct biosynthesis of ascorbic acid from glucose byXanthomonas campestristhrough induced free-radicals”, Biotechnology Letters, vol. 22, 2000, pp. 407-411.
Fujie Akihiko
Hino Motohiro
Hu Haifeng
Muramatsu Hideyuki
Ochi Kozo
Astellas Pharma Inc.
Mondesi Robert B.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Ochi Kozo
The National Food Research Institute
LandOfFree
Method for increasing productivity of secondary metabolite... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for increasing productivity of secondary metabolite..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for increasing productivity of secondary metabolite... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3908166