Method for increasing platelets by administering soluble interle

Details Method for increasing platelets by administering soluble interle Method for increasing platelets by administering soluble interle

1997-11-26

2000-02-22

Mertz, Prema

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 514885, 424 851, 424 852, A61K 3817, A61K 3819, A61K 3820

Patent

active

060280506

ABSTRACT:
A platelet-increasing preparation which comprises an effective amount of an interleukin-6 receptor and a pharmaceutically acceptable excipient. Preferably the preparation further comprises interleukin-6 and an ingredient selected from a stem cell factor, interleukin-3 and thrombopoietin.

REFERENCES:
patent: 5462731 (1995-10-01), Aderka et al.
Shigetaka Asano, et al.; In Vivo Effects of Recombinant Human Interleukin-6 in Primates: Stimulated Production of Platelets; Blood, 75(8): 1602-1605 (1990).
Toshiyuki Ishibashi, et al.; Interleukin-6 Is a Potent Thrombopoetic Factor in Vivo in Mice; Blood, 74:(4):1241-1244 (1989).
Xingwei Sui, et al.; gp130 and c-Kit Signalings Synergize for ex vivo Expansion of Human Primitive Hemopoietic Progenitor Cells; Proc. Natl. Acad. Sci. USA 92:2859-2863 (1995).
Sakura Tajima, et al.; Analysis of Interleukin 6 Receptor and pg130 Expressions and Proliferative Capability of Human CD34+ Cells; J. Exp. Med. 184:1357-1364 (1996).

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