Method for increasing nuclear magnetic resonance signals in livi

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

436173, 1286534, 4351731, 424643, G01N 2408, A61K 3332

Patent

active

052502848

ABSTRACT:
A method of enhancing a magnetic resonance signal comprising the steps of administering a quantity of a selected magnetic isotope to a living biological tissue at a concentration greater than the naturally occurring concentration of such isotope and detecting magnetic resonance signal from the administered magnetic isotope in the living biological tissue.

REFERENCES:
patent: 4351707 (1982-09-01), Turro
patent: 4532217 (1985-07-01), Springer, Jr. et al.
patent: 4672972 (1987-06-01), Berke
patent: 4731239 (1988-03-01), Gordon
patent: 4735796 (1988-04-01), Gordon
patent: 4779619 (1988-10-01), Winkler
patent: 4849210 (1989-07-01), Widder
patent: 4963344 (1990-10-01), Gries et al.
patent: 4985233 (1991-01-01), Klaveness et al.
Martino, A. F. Physiol. Chem. Physics & Med. NMR 15:481-7 (1983).
Schnall, M.D. Radiology 172:570-4 (1989).
Unkefer, C. J. J. Clin. Pharmacol. 26:452-8 (1986).
Evelhoch, J. L. Investigational New Drugs 7:5-12 (1989).
Narayan, P. Magnetic Resonance in Medicine 11:209-20 (1989).
Neurohr, K. J. et al. Adv. Myocardiol. 6:185-93 (1985).
Garbow, et al., "Characterization of Covalent Protein Conjugates Using Solid-State .sup.13 C NMR Spectroscopy," Biochemistry, 30, 7, 057-7,062 (1991).
Shimizu, et al., ".sup.43 Ca and .sup.67 Zn NMR Study of Ca.sup.2+, Zn.sup.2+ -Thermolysin Complexes," Biochemical and Biophysical Research Communication, vol. 104, No. 4, 1982.
Bhattacharyya, et al., "Nuclear Magnetic Resonance Investigation of Cadmium 113 Substituted Pea and Lentil Lectins," Journal of Biological Chemistry, vol. 262, No. 12, pp. 5616-5621 (1987).
Shimizu, T., Biochemical and Biophysical Research Communications, vol. 106, No. 3, (1982) 988-993.
Prout, Jr., et al., "Radioactive Zinc in the Prostate," J.A.M.A., vol. 169, No. 15, Apr. 11, 1959.
Johnston, et al., .sup.65 Zn and .sup.69m Zn Studies in the Dog, Monkey, and Man, Journal of Surgical Research, vol. 8, No. 11, Nov. 1968.
Gittes, "Carcinoma of the Prostate," The New England Journal of Medicine, vol. 324, No. 4, Jan. 24, 1991.
Quint, et al., "Carcinoma of the Prostate: MR Images Obtained with Body Coils Do Not Accurately Reflect Tumor Volume," AJR:156, pp. 511-516, Mar. 1991.
R. Damadian, "Tumor Detection by Nuclear Magnetic Resonance," reported in Science (171:1151-53, 1971).
C. S. Springer, Jr., "Measurement of Metal Cation Compartmentalization in Tissue by High-Resolution Metal Cation NMR," Ann. Rev. Biophys. Chem. 16:375-99, 1987.
R. L. Nunnally and P. R. Antich, "New Directions in Medical Imaging of Cancer" (Cancer 67:1271-1277, 1991).
H. Kantor, et al., "In Vivo .sup.31 P Nuclear Magnetic Resonance Measurements in Canine Heart Using a Catheter Coil" (Circ Res 55:261-266, 1984).
I. R. Francis, et al., "Malignant Hepatic Tumors: P-31 MR Spectroscopy with One-Dimensional Chemical Shift Imaging" Radiology 180:341-344 (1991).
Terrier, et al., "Effect of Intravenous Fructose on the P-31 MR Spectrum of the Liver: Dose Response in Healthy Volunteers," Radiology 171:557-563, 1989.
Crooks et al., "Tomography of Hydrogen with Nuclear Magnetic Resonance (NMR) and the Potential for Imaging Other Body Constituents" SPIE 206:120-128, 1979.
Hashimoto, et al., "Study of Biodistribution of Enflurane in Rats with In Vivo .sup.19 F MRI," Magnetic Resonance Imaging, vol. 9, pp. 557-581, 1991.
Otting, et al., "Protein-DNA Contacts in the Structure of a Homeodomain-DNA Complex Determined by Nuclear Magnetic Resonance Spectroscopy in Solution," The EMBO Journal, vol. 9, No. 10, pp. 3085-3092, 1990.
Summers, "Zinc Finger Motif for Single-Stranded Nucleic Acids? Investigations by Nuclear Magnetic Resonance," Journal of Cellular Biochemistry, 45:41-48 (1991).
Schnall, et al., "Prostate Cancer: Local Staging with Endorectal Surface Coil MR Imaging," Radiology 1991; 178:797-802.
Poon, et al., "MRI of Periprostatic Venous Plexus in Staging of Early Prostatic Carcinoma," Journal of the Canadian Association of Radiologists, vol. 39, pp. 111-114 (1988).
van Zijl, et al., "Complete Separation of Intracellular and Extracellular Information in NMR Spectra of Perfused Cells by Diffusion-Weighted Spectroscopy," Proc. Natl. Acad. Sci. USA, vol. 88, pp. 3228-3232, Apr. 1991.
Narayan, et al., "Characterization of Prostate Cancer, Benign Prostatic Hyperplasia and Normal Prostates Using Transrectal Phosphorus Magnetic Resonance Spectroscopy: A Preliminary Report," The Journal of Urology, vol. 146, pp. 66-74, Jul. 1991.
Beam, et al., "Status of Clinical MR Evaluation 1985-1988: Baseline and Design for Further Assessments," Radiology, vol. 180, No. 1, pp. 264-269 (1991).
Taylor, et al., "Free Magnesium Levels in Normal Human Brain and Brain Tumors: .sup.31 P Chemical-Shift Imaging Measurements at 1.5 T," Proc. Natl. Acad. Sci. U.S.A., vol. 88, pp. 6810-6814, Aug. 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for increasing nuclear magnetic resonance signals in livi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for increasing nuclear magnetic resonance signals in livi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for increasing nuclear magnetic resonance signals in livi will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1002138

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.