Method for increasing antibacterial effectiveness of a .beta.-la

Details Method for increasing antibacterial effectiveness of a .beta.-la Method for increasing antibacterial effectiveness of a .beta.-la

1979-10-22

1981-04-07

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

424271, A61K 3143

Patent

active

042605989

ABSTRACT:
6-Aminopenicillanic acid 1,1-dioxide, esters thereof readily hydrolyzable in vivo, and the pharmaceutically-acceptable salts of these compounds, are useful for enhancing the effectiveness of certain .beta.-lactam antibiotics against certain .beta.-lactamase producing bacteria. Derivatives of 6-aminopenicillanic acid 1,1-dioxide protected by a conventional carboxy protecting group are useful intermediates to 6-aminopenicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo.

REFERENCES:
patent: 3164604 (1965-01-01), Doyle et al.
patent: 3197466 (1965-07-01), Chow et al.
patent: 3536698 (1970-10-01), Chauvette et al.
patent: 3544581 (1970-12-01), Essery
patent: 3663563 (1972-05-01), Fosker et al.
patent: 3691188 (1972-09-01), Spry
patent: 3994912 (1976-11-01), Davis et al.
patent: 4164497 (1979-08-01), Kamiya et al.
patent: 4166904 (1979-09-01), Hunt
patent: 4180506 (1979-12-01), Pratt
C. Abstracts, vol. 76, P153735(n), (1972).
Abstracting, WGOLS 2,140,119.
Essery et al., J. Org. Chem., 30, 4388 (1965).
Guddal et al., Tetrahedron Letters, No. 9, 381 (1962).
Harrison et al., JCS, (London), Perkin I, 1972 (1976).
Chaikovskaya et al., Antibiotiki, 13, 155 (1968).
Cephalosporins & Penicillins, edited by E. Flynn, pp. 203-210 (1972), Academic Press.

Affiliated with

Also associated with

Rating

Method for increasing antibacterial effectiveness of a .beta.-la does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for increasing antibacterial effectiveness of a .beta.-la, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for increasing antibacterial effectiveness of a .beta.-la will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-288886