Radiant energy – Ionic separation or analysis – Methods
Patent
1992-04-24
1993-09-28
Dzierzynski, Paul M.
Radiant energy
Ionic separation or analysis
Methods
250281, H01J 4926
Patent
active
052488756
ABSTRACT:
A method is provided of increasing the resolution in a tandem mass spectrometer having a first quadrupole Q1 to select a parent ion, a second quadrupole Q2 which contains a target gas and forms a collision cell, and a third or analyzing quadrupole Q3 which generates a mass spectrum from daughter ions from Q2. In the method, the target thickness of the target gas in Q2 is held at least at 1.32.times.10.sup.15 cm.sup.-2, preferably at least 3.30.times.10.sup.15 cm.sup.-2, and the DC offset voltage between Q2 and Q3 is kept low or zero. This greatly improves the resolution available in Q3. Q3 is therefore operated with at least unit resolution, and in some cases with resolution of 1/2 or 1/3 amu, making it possible to resolve isotopes of singly, doubly or triply charged daughter ions.
REFERENCES:
patent: 4037100 (1977-07-01), Durser
patent: 4137750 (1979-02-01), French et al.
patent: 4328420 (1982-05-01), French
patent: 4814613 (1989-03-01), Fite et al.
patent: 4994165 (1991-02-01), Lee et al.
Paper entitled "High and Low Energy Collision Mass Spectrometry/Mass Spectrometry of Aza and Amino Polynuclear Aromatic Compounds in Coal-Derived Liquids", by Clupek et. al., published in Analytical Chemistry, 1982, 54, pp. 2215-2219.
Paper entitled "The Use of Triple Quadrupoles for Sequential Mass Spectrometry", by Dawson et. al., published in Organic Mass Spectrometry, vol. 17, No. 5, 1982, pp. 212-219.
Paper entitled "Mechanism of the Collision-Induced Dissociation of Polyatomic Ions Studies by Triple Quadrupole Mass Spectrometry", by D. J. Douglas, published in The Journal of Physical Chemistry, vol.. 86, No. 2, pp. 185-191.
Paper entitled "The Role of Kinetic Energy in Triple Quadrupole Collision Induced Dissociation (CID) Experiments", by B. Shushan et. al, published in International Journal of Mass Spectrometry and Ion Physics, vol. 46, 1983, pp. 71 and following.
Paper entitled "An Atmospheric-Pressure Ionization Mass Spectrometer/Mass Spectrometer", by Caldecourt et. al., International Journal of Mass Spectrometry and Ion Physics, vol. 49, 1983, pp. 233-251.
Paper entitled "A Hybrid BEQQ Mass Spectrometer", by A. E. Shoen et. al., published in International Journal of Mass Spectrometry and Ion Processes, 65 (1985), pp. 125-140.
Paper entitled "Performance of a Hybrid Mass Spectrometer", by J. D. Ciupek et. al., published in International Journal of Mass Spectrometry and Ion Processes, vol. 65, 1985, pp. 141-157.
Paper entitled "Tandem Mass Spectrometry of Peptides Using Hybrid and Four-Sector Instruments: A Comparative Study", by Mark F. Bean et. al., published in Analytical Chemistry, vol. 63, 1991, pp. 1473-1481.
Pp. 4-6 and 4-7 from manual published by Finnegan Corporation in the U.S. dated about Dec., 1990.
Pp. 15-19 from Finnegan Corporation manual for mass spectrometer instruments, precise date of publication unknown but before 1990.
Paper entitled "Tandem-in-Space and Tandem-in-Time Mass Spectrometry: Triple Quadrupoles and Quadrupole Ion Traps", by Jodie V. Johnson et. al., published in Analytical Chemistry, vol. 62, 1990, pp. 2162-2172.
Excerpt from text published in 1990 entitled "Methods in Enzymology, vol. 193, Mass Spectrometry", containing chapter entitled Tandem Mass Spectrometry: Quadrupole and Hybrid Instruments, by Yost et. al.
Paper entitled "Oligopeptide Sequence Analysis by Collision-activated Dissociation of Multiply Charged Ions", by Hunt et. al., published in Rapid Communications in Mass Spectrometry, vol. 3, No. 4, 1989, pp. 122-124.
Paper entitled "High-resolution tandem mass spectrometry of large biomolecules", by Loo et. al., published in Proc. National Academy of Science USA, vol. 89, Jan. 1992, pp. 286-289.
Corr Jay
Douglas Donald
Hager James
Thomson Bruce
Dzierzynski Paul M.
MDS Health Group Limited
Nguyen Kiet T.
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