Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1993-01-28
1994-11-01
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
435 2, C12N 706, A01N 102
Patent
active
053607341
ABSTRACT:
The present invention provides a method for inactivating pathogens in a body fluid, such as plasma, red cells, platelets, leukocytes, and bone marrow. The present invention minimizes adverse effects caused by the photosensitive agents while retaining the disinfecting activity of such agents and processes. Pursuant to the present invention, prior to irradiating a body fluid including a photoactive drug, the extracellular fluid, which in the case of blood components includes plasma proteins is at least substantially reduced. Additionally, after the irradiation process, the resultant body fluid is prevented from contacting additional extracellular fluid, e.g., plasma proteins, for a predefined period.
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H. C. Neyndorff et al, "Development of a Model to Demonstrate Photo-sensitizer-Mediated Viral Inactivation in Blood", Transfusion, vol. 30, No. 6, 1990, pp. 485-490.
Chapman John
Logan Patricia M.
Neyndorff Herma C.
North Janice
Baxter International Inc.
Quadra Logic Technologies Inc.
Robinson Douglas W.
Saucier Sandra
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