Method for inactivating pathogens in compositions containing cel

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits

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435 2, C12N 706, A01N 102

Patent

active

055977227

ABSTRACT:
The present invention provides a method for inactivating pathogens in a body fluid, such as plasma, red cells, platelets, leukocytes, and bone marrow. The present invention minimizes adverse effects caused by the photosensitive agents while retaining the disinfecting activity of such agents and processes. Pursuant to the present invention, prior to irradiating a body fluid including a photoactive drug, the extracellular fluid, which in the case of blood components includes plasma proteins is at least substantially reduced. Additionally, after the irradiation process, the resultant body fluid is prevented from contacting additional extracellular fluid, e.g., plasma proteins, for a predefined period.

REFERENCES:
patent: 5360734 (1994-11-01), Chapman et al.
patent: 5459030 (1995-10-01), Lin et al.
De Paolis A et al, Biochem J. 226:757-766 (1985).
Prodouz KN et al, Transfusion 31:415-422 (1991).

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