Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1995-06-02
1998-12-22
Schwadron, Ronald B.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
435325, 435355, 435372, 435378, 435384, 435395, 530351, C12N 500, C12N 502, C12N 508, A01N 102
Patent
active
058517561
ABSTRACT:
A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
REFERENCES:
patent: 4861589 (1989-08-01), Ju
Inaba, Kayo et al.; "Identification of Proliferating Dendritic Cell Precursors in Mouse Blood"; The Journal of Experimental Medicine, May 1992, vol. 175, pp. 1157-1167.
Scheicher, Christoph et al.; "Dendritic Cells From Mouse Bone Marrow: In Vitro Differentiation Using Low Doses of Recombinant Granulocyte-Macrophage Colony-Stimulating Factor"; Journal of Immunological Methods, 1992, vol. 154, pp. 253-264.
Steinman, Ralph M.; "The Dendritic Cell System and Its Role in Immunogenicity", Annual Review in Immunology, 1991, vol. 9, pp. 271-296.
Freudenthal, Peter S. and Ralph M. Steinman; "The Distinct Surface of Human Blood Dendritic Cells, As Observed After An Improved Isolation Method"; Proceedings of the National Academy of Sciences, Oct. 1990, vol. 87, No. 19, pp. 7698-7702.
Inaba, Kay et al.; "Dendritic Cells Pulsed With Protein Antigens In Vitro Can Prime Antigen-Specific, MHC-restricted T Cells In Situ", Journal of Experimental Medicine, Aug., 1990, vol. 172, No. 2, pp. 631-640.
Vakkila, J. et al.; "Human Peripheral Blood-Derived Dendritic Cells Do Not Produce Interleukin 1.alpha., Interleukin 1.beta. or Interleukin 6"; Scandinavian Journal of Immunology, 1990, vol. 31, pp. 345-352.
Crowley, Mary et al.; "Dendritic Cells Are the Principal Cells in Mouse Spleen Bearing Immunogenic Fragments of Foreign Proteins"; Journal of Experimental Medicine; Jul. 1990, vol. 172, pp. 383-386.
Koch, Franz et al.; "Tumor Necrosis Factor .alpha. Maintains The Viability Of Murine Epidermal Langerhans Cells In Culture, But In Contrast To Granulocyte/Macrophage Colony-Stimulating Factor, Without Inducing Their Functional Maturation"; The Journal of Experimental Medicine; Jan. 1, 1990, vol. 171, pp. 159-171.
MacPherson G.G.; "Lymphoid Dendritic Cells: Their Life History and Roles in Immune Responses", Research in Immunology, 1989, vol. 140, pp. 877-926.
Barfoot, R. et al., "Some Properties of Dendritic Macrophages From Peripheral Lymph", Immunology, Oct. 1989, vol. 68, pp. 233-239.
MacPherson, G. G. et al.; "Properties of Lymph-Borne (Veiled) Dendritic Cells in Culture", Immunology, Sep. 1989, vol. 68, pp. 108-113.
Witmer-Pack, Margit D. et al.; "Granulocyte/Macrophage Colony-Stimulating Factor Is Essential For The Viability and Function of Cultured Murine Epidermal Langerhans Cells"; The Journal of Experimental Medicine, Nov. 1987, vol. 166, No. 1, pp. 1484-1498.
Schuler, Gerold et al.; "Epidermal Langerhans Cells Represent Immature Dendritic Cells That Must Differentiate Prior To Expressing Their Full Immunologic Potential", Investigative Dermatology; Jul. 1986, vol. 87, No. 1, p. 166.
Bowers, William E. and Mary R. Berkowitz; "Differentiation of Dendritic Cells In Cultures of Rat Bone Marrow Cells"; The Journal of Experimental Medicine; Apr. 1986, vol. 163, pp. 872-883.
Inaba, Kayo et al.; "Properties Of Memory T Lymphocytes Isolated From The Mixed Leukocyte Reaction"; Proceedings of the National Academy of Sciences; Nov. 1985, vol. 82, pp. 7686-7690.
Francotte, M. and J. Urbain; "Enhancement of Antibody Response by Mouse Dendritic Cells Pulsed With Tobacco Mosaic Virus Or With Rabbit Antiidiotypic Antibodies Raised Against a Private Rabit Idiotype"; Proceedings of the National Academy of Sciences; Dec. 1985, vol. 82, pp. 8149-8152.
Inaba, Kayo and Ralph M. Steinman; Protein Specific Helper T-Lymphocyte Formation Initiated By Dendritic Cells; Science; Aug. 1985, vol. 299, pp. 475-479.
Inaba, Kayo et al.; "Clustering of Dendritic Cells, Helper T Lymphocytes, and Histocompatible B Cells During Primary Antibody Responses In Vitro"; The Journal of Experimental Medicine; Sep. 1984, vol. 160, pp. 858-876.
Knight, Stella C. et al.; "Role of Veiled Cells In Lymphocyte Activaton"; European Journal of Immunology, Dec. 1982, vol. 12, pp. 1057-1060.
Kraal, Georg, et al.; "Langerhans' Cells, Veiled Cells, And Interdigitating Cells In The Mouse Recognized By a Monoclonal Antibody"; The Journal of Experimental Medicine, May 1986, vol. 163, pp. 981-997.
Inaba, Kayo and Ralph M. Steinman; "Resting and Sensitized T Lymphocytes Exhibit Distinct Stimulatory (Antigen-Presenting Cell) Requirements For Growth And Lymphokine Release"; The Journal of Experimental Medicine; Dec. 1984, vol. 160, pp. 1717-1735.
Klinkert, Wolfgang E.F. et al.; "Accessory and Stimulating Properties of Dendritic Cells and Macrophages Isolated From Various Rat Tissues"; The Journal of Experimental Medicine, Aug. 1982, vol. 156, pp. 1-19.
Van Voorhis, Wesley C. et al.; "Human Dendritic Cells"; The Journal of Experimental Medicine, Apr. 1982, vol. 155, pp. 1172-1187.
Mason, D.W. et al.; "The Rat Mixed Lymphocyte Reaction: Roles Of A Dendritic Cell In Intestinal Lymph and T-Cell Subsets Defined By Monoclonal Antibodies"; Immunology; Sep. 1981, vol. 44, pp. 75-87.
Steinman, Ralph M. et al.; "Identification Of a Novel Cell Type In Peripheral Lymphoid Organs Of Mice"; The Journal of Experimental Medicine; Feb. 1979, vol. 149, pp. 1-16.
Steinman, Ralph M. and Zanvil A. Cohn; "Identification Of A Novel Cell Type In Peripheral Lymphoid Organs Of Mice"; The Journal of Experimental Medicine, Apr. 1973, vol. 137, pp. 1142-1162.
Caux, Christophe, et al.; "Tumor Necrosis Factor-alpha Strongly Potentiates Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor-Induced Proliferation of Human CD34.sup.+ Hematopoietic Progenitor Cells"; Blood, Jun. 1990, vol. 75, pp. 2292-2298.
"Peripheral Stem Cells Made to Work"; The Lancet, Mar. 1992, vol. 339, pp. 648-649.
Boog, Clair J.P., et al.; "Abolition of Specific Immune Response Defect by Immunization with Dendritic Cells"; Nature, Nov. 1985, vol. 318, pp. 59-62.
Rudensky, Alexander Yu, et al.; "Sequence Analysis of Peptides Bound to MHC Class II Molecules"; Nature, Oct. 1991, vol. 353, pp. 622-627.
Faustman, Denise L., et al.; "Prevention of Rejection of Murine Islet Allografts by Pretreatment with Anti-Dendritic Cell Antibody"; Proceedings of the National Academy of Sciences, Jun. 1984, vol. 81, pp. 3864-3868.
Ziegler, H. Kirk and Unanue, Emil R.; "Decrease in Macrophage Antigen Catabolism Caused by Ammonia and Chloroquine is Associated with Inhibition of Antigen Presentation to T Cells"; Proceedings of the National Academy of Sciences, Jan. 1982, vol. 79, pp. 175-178.
Lechler, R.I. and Batchelor, J.R.; "Restoration of Immunogenicity to Passenger Cell-Depleted Kidney Allografts by the Addition of Donor Strain Dendritic Cells"; The Journal of Experimental Medicine, Jan. 1982, vol. 155, pp. 31-41.
Shimonkevitz, Richard, et al.; "Antigen Recognition by H-2-Restricted T Cells"; The Journal of Experimental Medicine, Aug. 1983, vol. 158, pp. 303-316.
Bujdoso, Raymond, et al.; "Characterization of Sheep Afferent Lymph Dendritic Cells and their Role in Antigen Carriage"; The Journal of Experimental Medicine, Oct. 1989, vol. 170, pp. 1285-1302.
Holt, Patrick G., et al.; "MHC Class II Antigen-Bearing Dendritic Cells in Pulmonary Tissues of the Rat"; The Journal of Experimental Medicine, Feb. 1988, vol. 167, pp. 262-274.
Britz, J.S., et al.; "Specialized Antigen-Presenting Cells, Splenic Dendritic Cells and Peritoneal-Exudate Cells Induced by Mycobacteria Activate Effector T Cells that are Resistant to Suppression"; The Journal of Experimental Medicine, May 1982, vol. 155, pp. 1344-1356.
Iwai, Hiroshi, et al.; "Acceptance of Murine Thyroid Allogra
Inaba Kayo
Schuler Gerold
Steinman Ralph M.
Schwadron Ronald B.
The Rockefeller University
LandOfFree
Method for in vitro proliferation of dendritic cell precursors a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for in vitro proliferation of dendritic cell precursors a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for in vitro proliferation of dendritic cell precursors a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2045631