Method for in vitro determination of transdermal absorption

Details Method for in vitro determination of transdermal absorption Method for in vitro determination of transdermal absorption

1986-08-29

1988-09-13

Richman, Barry S.

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Surface area, porosity, imperfection, or alteration

424 95, 424DIG7, 73 643, A61K 3558, G01N 710

Patent

active

047710047

ABSTRACT:
Provided is a novel barrier membrane and a method using the barrier membrane for testing the transdermal penetration behavior of a bioactive agent. The method employs shed snake skin as the model barrier membrane. In particular, the method comprises the steps of providing a dose of a donor formulation containing the bioactive agent, and a receptor solution, with a barrier membrane of shed snake skin separating the donor formulation and receptor solution. The receptor solution is then serially sampled and assayed in order to determine the concentration of the bioactive agent in the receptor solution. The use of the shed snake skin has been found to provide reproducible and uniform results as a model barrier membrane. As well, the shed snake skin offers the advantages of being readily available and storable for an extended period of time.

REFERENCES:
patent: 3590634 (1971-07-01), Pasternak
patent: 4594884 (1986-06-01), Bondi et al.

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