Method for improving tissue antioxidant status

Details Method for improving tissue antioxidant status Method for improving tissue antioxidant status

1994-07-29

1996-05-14

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514264, 514309, A61K 3152, A61K 3147

Patent

active

055167780

ABSTRACT:
The invention relates to a method of using 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione (generic name:pentoxifylline) and/or 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4 -dihydroisoquinolinium theophylline-7-acetate (Depogen) or monohydrate thereof to improve mammalian tissue antioxidant status. This status plays an important role in complications, occurring as a consequence of pathologically developed or artificially established anastomoses, particularly anastomosis of oesophagus and colon since these organs possess a very weak antioxidant protective system.

REFERENCES:
Obstet. Gynecol. 75 (6), 1990, pp. 147-157.
Ellis, H., "The Cause and Prevention of Postoperative Peritoneal Adhesion", Surg. Gynec. Obstet, 133: 497 to 511 (Sep. 1971).
Sawyers et al, "The Acute Abdomen. In: The Surgical Clinics of North America", 68, (2), 353 to 364 (Apr. 1988).
Soliman, M. H. et al, "Pentoxifylline Improves Tissue Oxygenation Following Anaesthesia and Operation", Crit. Care Med. 15, 93 to 94 (1987).
CA 118:116687, Kumar et al., 1992.
CA 121:148666, Kang et al., 1993.

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