Method for improving the quality of sperm for artificial...

Details Method for improving the quality of sperm for artificial... Method for improving the quality of sperm for artificial...

2005-05-10

2005-05-10

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C424S561000, C600S035000, C604S906000

Reexamination Certificate

active

06890708

ABSTRACT:
A method and composition for artificial insemination. The method involves artificially inseminating the subject with sperm, wherein the sperm is combined or coadministered with an inhibitor of phosphodiesterase and preferably a soluble salt of an earth alkaline metal. The composition comprises phosphodiesterase inhibitor or a functional equivalent thereof, a soluble salt of an earth alkaline metal and sperm. The method and composition reduce the recruitment of polymorphonuclear neutrophils.

REFERENCES:
patent: 6140121 (2000-10-01), Ellington et al.
patent: WO 97 14785 (1997-04-01), None
patent: WO 99 61010 (1999-12-01), None
patent: WO 0180867 (2001-11-01), None
Abbydeera et al., In Vitro Penetration of Pig Oocytes in a Modified Tris-Buffered Medium: Effect of BSA, Caffeine and Calcium, Theriogenology, 1997, pp. 537-534, vol. 48.
Aitken et al., Influence of Caffeine on Movement Characteristics, Fertilizing Capacity and Ability to Penetrate Cervical Mucus of Human Spermatozoa, Journal of Reproduction & Fertility, 1983, pp. 19-27, vol. 67.
Thibault, et al., Adenosine Receptor Occupancy Suppresses Chemoattractant-induced Phospholipase D Activity by Diminishing Membrane Recruitment of Small GTPases, Blood, Jan. 15, 2000, vol. 95, No. 2.
Kalab et al., Regulation of Protein Tyrosine Phosphorylation in Boar Sperm Through a cAMP-Dependent Pathway, Molecular Reproduction and Development, 1998, pp. 304-314, vol. 51.
PCT International Search Report, PCT/NL01/00314, dated Aug. 1, 2001, 4 pages.
PCT International Preliminary Examination Report, PCT/NL01/00314, dated Aug. 19, 2002, 8 pages.

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