Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1996-06-07
1997-10-28
Feisee, Lila
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436523, 436528, 436529, 436530, 436531, 436533, 436534, 436823, 436548, 436810, 435 4, 435 79, 435962, 435963, G01N 33543, G01N 33544, G01N 33546, C12Q 100
Patent
active
056817541
ABSTRACT:
A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.
REFERENCES:
patent: 5252459 (1993-10-01), Tarcha et al.
P. J. Tarcha, et al., "Synthesis, Analysis, and Immunodiagnostic Applications of Polypyrrole Latex and Its Derivatives", American Chemial Society, vol. 492, 1992, pp. 347-367.
J. F. Pritchard, et al., "Determination of Vicinal Hydroxyl Groups in Poly(Vinyl Alcohol) (PVA)", Talanta, vol. 23, 1975, pp.237-239.
Joseph Mary K.
Mees David R.
Pope Mark R.
Pry Terry A.
Putman C. Brent
Abbott Laboratories
Feisee Lila
Huff Sheela J.
Weinstein David L.
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