Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Reexamination Certificate
2006-08-22
2006-08-22
Kemmerer, Elizabeth (Department: 1649)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
C435S007310, C435S069700, C435S069500, C435S254200, C435S254210, C435S320100, C436S501000, C536S023500, C530S350000
Reexamination Certificate
active
07094593
ABSTRACT:
This invention relates to mutant G protein-coupled receptors with improved G-protein coupling and receptor response, yeast cells expressing such receptors, vectors useful for making such cells, and methods of making and using same.
REFERENCES:
patent: 5576210 (1996-11-01), Sledziewski
patent: 5789184 (1998-08-01), Fowlkes
patent: WO95/21925 (1995-08-01), None
patent: WO96/00739 (1996-01-01), None
patent: WO 96/00739 (1996-01-01), None
patent: WO 92/05244 (1996-04-01), None
patent: WO 98/38217 (1998-09-01), None
patent: WO00/22131 (2000-04-01), None
Bonner et al., Science 237(527-537)1987.
Feng-y et al., Molecular and Cellular Biology, 20(5)563-574)2000.
Eggerickx, D., et al., “Molecular Cloning of an Orphan G-Protein-Coupled Receptor that Constitutively Activates Adenylate Cyclase”,Biochemical J.309:837-843, 1995.
Kjelsberg, M.A., et al., “Constitutive Activation of the Alpha 1B-Adrenergic Receptor by all Amino Acid Substitutions at a Single Site”,J. Biol. Chem.267(3):1430-1433, Jan. 1992.
Pauwels, P.J. and T. Wurch, “Review: Amino Acid Domains Involved in Constitutive Activation of G-Protein-Coupled Receptors”,Mol. Neurobiol.17(1-3):109-135, 1998.
Samama, P., et al., “A Mutation-Induced Activated State of the Beta2-Adrenergic Receptor”,J. Biol. Chem.268(7):4625-4636, Mar. 1993.
M.H. Pausch et al., “G-Protein-Coupled receptors inSaccharom yces cerevisiae:high-throughput screening assays for drug discovery”,Trends in Biotechnology, vol. 15, No. 12, pp. 487-494, (Dec. 1997).
O. Moro, et al., “Serine-and Threonine-rich Domain regulates internaliz ation of muscarinic cholinergic Receptors”,Jo urnal of Biological Chemistry, vol. 268, No. 10, pp. 6862-6865 (Apr. 1993).
K. Blueml, et al., “Functional Role of A Cytoplasmic Aromatic Amino Acid In Muscarinic Receptor-Mediated Activ ation of Phospholipase C”,Jo urnal of Biological Chemistry, vol. 269, No. 15, pp. 11537-11541, (Apr. 1994).
J. Wess, et al., “Identification of a small intracelular region of the mascarinic m3 receptor as a determinant of selective coupling to PI turnov er”,FEBS Letters, vol. 258, No. 1, (Nov. 1989).
J. Wess, et al., “G protein-coupled receptors: m olecular mechanisms involved in receptor activation and selectiv ity of G-protein recognition”FASEB Jo urnal, US, Fed. of American Soc. for Experimental Biology, vol. 11, No. 5, pp. 346-354, (Apr. 1997).
M.H. Pausch, etal., “Heterologous G Protein-Coupled Receptors Ex pressed inSaccharom yces cerevisiae: Methods for Genetic Analy sis and Ligand Identif ication”,Identification and Expression of G-Protein-Coupled Receptors, pp. 196-212 (May 1999).
A. Scheer, et al., “Constitutiv ely Active G Protein-Coupled Receptors: Potential M echanisms of Receptor Activ ation”Journal of Receptor and Signal Transduction Research, vol. 17, No. 1-3, pp. 57-73, (1997).
Pausch Mark Henry
Wess Jurgen
BASF - Aktiengesellschaft
Brannock Michael
Finnegan Henderson Farabow Garrett & Dunner LLP
Kemmerer Elizabeth
The United States of America as represented by the Department of
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