Method for improving pharmacokinetics

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Enzyme inactivation by chemical treatment

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Details

548204, 548205, 514365, C12N 999, C07D27728

Patent

active

060371579

ABSTRACT:
A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.

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S. Vella, Rationale and Experience with Reverse Transcriptase Inhibitors and Protease Inhibitors, Journ of Acquired Immune Def. Syndrome & Humane Retro. 10(Suppl. 1) S58-S61 1995.
J. Craig, et al., Int. Conf. AIDS 9(1993) PO-A25-0602 RO 31-8959, An Inhibitor of HIV Proteinase, Acts Beneficially with Other Antiviral Agents in 2- and 3-Way Combinations In Vitro.
D, Kempf, et al., 3rd Conf Retro and Opportun Infect (US) Jan. 28-Feb. 1, 1996 p. 79.
J. James, AIDS Treatment News, No. 231 Sep. 29, 1995.

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