Method for improving optical purity of an amine compound

Details Method for improving optical purity of an amine compound Method for improving optical purity of an amine compound

1997-12-12

1999-10-12

Kumar, Shailendra

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

564336, 564307, 435830, C12P 1300, C12P 4100

Patent

active

059654325

ABSTRACT:
There is provided a method for improving optical purity of an amine compound of the formula I: ##STR1## wherein R.sup.1 indicates a phenyl group which may be substituted or an aralkyl group having 7 to 10 carbon atoms which may be substituted, and R.sup.2 indicates an alkyl group having 1 to 6 carbon atoms, which is characterized by contacting a cutlture of a microorganism belonging to Arthrobacter having an ability to preferentially metabolize one optical isomer based on an asymmetric carbon atom to which an amino group bonds in the amine compound of the formula I or a treated product thereof with the amine compound of the formula I.

REFERENCES:
patent: 4950606 (1990-08-01), Stirling et al.
Jong-Shik Shin et al., Biotechnology and Bioengineering, 55(2):348-358.
CA:126:342536 abs of WO9715682, May 1997.
CA:117:110028 by Shimizu in Appl Microbio Biotechnol 37(2) pp. 164-168, 1992.
CA: 117:169596 abs of JP04126096, Apr. 1992.

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