Method for improving delivery and reducing toxicity of biologica

Details Method for improving delivery and reducing toxicity of biologica Method for improving delivery and reducing toxicity of biologica

1993-03-31

1994-12-06

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 560169, 560170, 560171, A61K 9127

Patent

active

053708776

ABSTRACT:
.alpha.-Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of biologically active substances by encapsulation of the biologically active substance with the above compounds.

REFERENCES:
Kunitake, J. Macromol. Sci., Chem., A21 (8-9), pp. 1232-1252 (1984).
Kunitake, J. Am. Chem. Soc., 103 (19) pp. 5945-5947 (1981).
Poznansky et al. Pharmacological Reviews 36 #4, p. 277, 1984.

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