Method for improving blood compatibility of interpenetrating mul

Details Method for improving blood compatibility of interpenetrating mul Method for improving blood compatibility of interpenetrating mul

1997-12-23

2000-12-05

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

623 11, 623 12, C08L 7504, A61L 2700, A61F 206

Patent

active

061563447

ABSTRACT:
The present invention provides a method for improving blood compatibility of interpenetrating multicomponent polymer by controlling various factors affecting phase separation such as composition ratio, synthetic temperature, synthetic pressure, cross-linking density and hydrophilicity of polyurethane in the course of synthesizing interpenetrating polymer network ("IPN") where hydrophilic urethane resin and hydrophobic styrene derivative are cross-linked each other. IPN materials of the invention may be widely used in various applications such as artificial organ or surface finishing material which are in direct contact with blood, since they inhibit thrombogenesis by suppressing platelet adhesion and agglutination.

REFERENCES:
patent: 4302553 (1981-11-01), Frisch et al.
patent: 5395888 (1995-03-01), Franke et al.
Advances in Chem. Series (239/1994 ACS Interpenetrating Polymer Networks pp. 28-31, 307-309 Ed. Klempner et al.
T. Okano et al J. of Biomedical Research, vol. 20, 919-927 (1986).
T. Okano et al., Hydrophilic-hydrophobic Microdomain Surfaces Having an Ability to Supress Platelet Aggregation and Their in vitro Antithrombogenicity, J. Biomed. Mater. Res., 20, 919-927 (1986).
Y.H. Kim et al., Negative Cilia Concept for Thromboresistance: Synergistic effect of PEO and Sulfonate Groups Grafted onto Polyurethanes, J. Biomed. Mater. Res., 25, 561-575 (1991).

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