Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1993-02-09
1996-09-03
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424447, 424445, 424446, 424 7802, 514356, 514211, 514648, 514 2258, 514649, A61K 31275
Patent
active
055521622
ABSTRACT:
A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar. Further disclosed is a method for improving the size and appearance of a scar comprises covering said scar with a thermal insulating material that elevates the surface temperature of the scar and that contains a therapeutically effective amount of a medicament.
REFERENCES:
patent: 4272518 (1981-06-01), Moro et al.
patent: 4659700 (1987-04-01), Jackson
patent: 5013769 (1991-05-01), Murray et al.
patent: 5132119 (1992-07-01), Lee
Ahn et al., "Topical Silicone Gel for the Prevention and Treatment of Hypertrophic Scar," Arch Surg., 126:499-504, 1991.
Fulton, "The Stimulation of Postdermabrasion Wound Healing with Stabilized Aloe Vera Gel-Polyethylene Oxide Dressing," J. Dermatol. Surg. Oncol., 16(5):460-467, 1990.
Krieger et al.,"Thermal Response of the Epidermis to Surface Cells," 49th Annual Sessions on the forum on Fundamental Surgical Problems, 1993 Clinical Congress, San Francisco, CA, Oct. 10-15, pp. 738-740.
Lee et al., "The Response of Burn Scars to Intralesional Verapamil," Arch Surg. 129:107-111, 1994.
Lee and Ping, "Calcium Antagonists Retard Extracellular Matrix Production in Connective Tissue Equivalent," Journal of Surgical Research, 49:463-466, 1990.
Ehrlich and Buttle, "Epidermis Promotion of Collagenase in Hypertrophic Scar Organ Culture," Experimental and Molecular Pathology, 40:223-234, 1984.
International Search Report dated Jul. 2, 1994.
Ahn et al. (1989) Surgery vol. 106, No. 4, pp. 781-787.
Clinical Comment (1980), vol. 6, No. 3, pp. 1-3.
Jeffrey et al. (1983) The Journal of Biological Chemistry, vol. 258, No. 18, pp. 11123-11127.
Quinn, et al. (1985) Burns 12:102-108.
Quinn, (1987) Burns 13:S33-S40.
Welgus, et al. (1980) The Journal of Biological Chemistry, vol. 256, No. 18, pp. 9511-9515.
Welgus, et al. (1980) The Journal of Biological Chemistry, vol. 256, No. 18, pp. 9516-9521.
ARCH Development Corporation
Barts Samuel
Dees Jos,e G.
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