Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-05-17
2011-05-17
Joike, Michele K (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S252300, C435S008000
Reexamination Certificate
active
07943300
ABSTRACT:
This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this respect, the invention offers a technology to improve the yield of functionally expressed recombinant proteins.
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Horn Uwe
Riesenberg Ulrike
Strittmatter Wolfgang
Joike Michele K
Merck Patent GmbH
Millen White Zelano & Branigan P.C.
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