Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1993-05-03
1993-11-16
Housel, James C.
Chemistry: analytical and immunological testing
Biological cellular material tested
436 17, 436 18, 436176, G01N 128
Patent
active
052623297
ABSTRACT:
A lytic reagent composition highly selective in its interactions with the cell membranes of blood cells and also provides a method of using the reagent composition in a semi-automated or an automated system to effect a significantly improved white blood cell differential determination. The lytic reagent composition is characterized by an ability to selectively shrink the white blood cells into the increasing size order of lymphocytes, a midregion consisting mainly of monocytes, other mononuclear cells, some basophils and eosinophils, and neutrophils and can readily be optimized to effect a significantly improved three component separation on the histogram of commercially available semi-automated and automated blood analyzers when compared to the reagents conventionally employed on such instruments. Also provided is a novel blood diluent that exhibits an improved ability to stabilize blood cells without "fixing" the permeability of their membranes, which is critical in the semi-automated analysis or blood cells. This mechanism for membrane stability is particularly effective for maintaining the morphology and size distribution of blood cells for multiple species of animals.
REFERENCES:
patent: 3634581 (1972-01-01), Thomas
patent: 3741875 (1973-06-01), Ansley et al.
patent: 4213876 (1980-07-01), Crews et al.
patent: 4286963 (1981-09-01), Ledis et al.
patent: 4346018 (1982-08-01), Carter et al.
patent: 4485175 (1984-11-01), Ledis et al.
patent: 4529705 (1985-07-01), Larsen
patent: 4745071 (1988-05-01), Lapicola et al.
patent: 4751179 (1988-06-01), Ledis et al.
patent: 4962038 (1990-10-01), Carter et al.
patent: 5155044 (1992-10-01), Ledis et al.
Housel James C.
Snay Jeffrey R.
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