Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific...
Patent
1993-03-05
1995-06-13
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
4242831, A61K 3720, A61K 3722
Patent
active
054240689
ABSTRACT:
Pharmaceutical compositions and a method for immunization of mammals against atherosclerosis including steps of a) obtaining blood from a mammal; b) isolating low density lipoprotein from the blood; c) fusing the lipoprotein in vitro to obtain heavy microemulsion lipoprotein fusion particles having new antigenic determinants; d) administering the fusion particles obtained in step (c) to a mammal; and e) allowing the immune system to clear fusion lipoprotein particles from the mammal.
REFERENCES:
patent: 4891220 (1990-01-01), Donzis
Joseph L. Witztum 1993. Role of oxidised low density lipoprotein in atherogenesis. British Heart journal No. 69 Supplement pp. S12-S18.
Fusion of Low Density Lipoproteins with Cholesteral Ester-Phospholipid Microemulsions, Parks et al. J. Biol Chem. 1985 260(5)3155-63.
Modification of Low Density Lipoproteins by Secretaoy Granules of Rat Serosal Mast Cells Kovanen and Kokkonen 1991 266(7):4430-36 J. Biol. Chem.
Technological Advances in Vaccine Development ed. Laurence Lasky .COPYRGT.1988 pp. 401-409.
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Minnifield Nita M.
Nucker Christine M.
P. Doina International Ltd.
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