Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1991-12-20
1998-09-15
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
530350, 5303911, 5303913, 5303915, 5303917, 5303919, 530402, 530404, 530408, 525 61, 536 111, 536 92, 435180, C07K 1600, C07H 100, C08B 1100, C08F 800
Patent
active
058079971
ABSTRACT:
A method for the immobilization of an organic thiol compound, HS--R, in which R is an organic residue, to a water-insoluble polymer of non-polypeptide structure exhibiting a disulfide (--S--S--) group directly bound to a saturated carbon atom at each of its sulphur atoms, which comprising contacting the polymer with an oxidation agent in such an amount and of such a kind that it is capable of transforming the disulfide group (--S--S--) to an oxidized disulfide group capable of reacting with thiol groups, whereupon the polymer obtained exhibiting one or more oxidized disulfide groups is contacted with the organic thiol compound HS--R under conditions allowing reaction to the formation of one --S--S--R group and one --SO.sub.n (H) group per disulfide oxide group that undergoes the reaction, where n is 1 or 2.
REFERENCES:
patent: 4175073 (1979-11-01), Axen et al.
patent: 4558006 (1985-12-01), Egrie
MacLaren et al.--Aust. J. Chem., 18(1965) 1655-65.
MacLaren et al--J. Soc. Dyers and Colourists, (1968-11) 564-67.
Rajca et al--Tetrahedron Letters, 31 (1990) 42 A pp. 6075-6076.
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