Chemistry: analytical and immunological testing – Optical result – With claimed manipulation of container to effect reaction or...
Patent
1992-12-18
1994-05-24
Alexander, Lyle A.
Chemistry: analytical and immunological testing
Optical result
With claimed manipulation of container to effect reaction or...
436 56, 436 94, 436164, 422 58, 422 8205, 422102, 422104, 435 6, 250306, 250307, 250311, 25044011, 356244, 935 77, G01N 2103
Patent
active
053148290
ABSTRACT:
Imaging biological molecules such as DNA at rates several times faster than conventional imaging techniques is carried out using a patterned silicon wafer having nano-machined grooves which hold individual molecular strands and periodically spaced unique bar codes permitting repeatably locating all images. The strands are coaxed into the grooves preferably using gravity and pulsed electric fields which induce electric charge attraction to the molecular strands in the bottom surfaces of the grooves. Differential imaging removes substrate artifacts.
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Alexander Lyle A.
California Institute of Technology
Keller Michael L.
Wallace Robert M.
Wallenhorst Maureen M.
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