Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-11-20
2010-02-09
Woitach, Joseph (Department: 1633)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S372000, C435S456000
Reexamination Certificate
active
07659058
ABSTRACT:
The present invention relates to a method for the detection of epitope-specific T-cells and target epitopes of reactive T-cells. Furthermore, the present invention relates to vectors comprising a first promoter which is specifically inducible by the epitope-specific contact with a T-cell in antigen-presenting cells, a nucleic acid which is functionally linked to this first promoter and which encodes a marker gene, a second promoter which is constitutive in antigen-presenting cells, and a nucleic acid which is functionally linked to said second promoter. Furthermore, the present invention relates to antigen-presenting cells which are transduced with the vectors according to the invention.
REFERENCES:
patent: WO 97/26325 (1997-07-01), None
patent: WO 00/57705 (2000-10-01), None
patent: WO 00/67761 (2000-11-01), None
patent: WO 01/32204 (2001-05-01), None
Linette et al., 2000, J. Immunol. 164:3402-3412.
den Haan et al., 2000, PNAS 97:12950-12952.
Bishop and Hostager, “B lymphocyte activation by contact-mediated interactions with T lymphocytes,”Current Opinion in Immunology, 13:278-285, 2001.
Clarke, “The critical role of CD40/CD40L in the CD4-dependent generation of CD8+T cell immunity,”Journal of Leukocyte Biology, 67:607-614, 2000.
Cui et al., “Targeting transgene expression to antigen presenting cells (APC) differentiated in vivo from lentiviral transduced, engrafting human and mouse hematopoietic stem/progenitor cells,”Blood, 98(11):214a, abstract, 2001.
den Haan and Bevan, “A novel helper role for CD4 T cells,”Proc. Natl. Acad. Sci., USA, 97(24):12950-12952, 2000.
Ohshima et al., “Expression and function of OX40 ligand on human dendritic cells,”Journal of Immunology, 159:3838-3849, 1997.
Takayama et al., “Translation of dendritic cell progenitors with a retroviral vector encoding viral interleukin-10 and enhanced green fluorescent protein allows purification of potentially tolerogenic antigen-presenting cells,”Transplantation, 68(12):1903-1909, 1999.
Weinberg et al., “OX-40: life beyond the effector T cell stage,”Immunology, 10:471-480, 1998.
Fulbright & Jaworski
Hiriyanna Kelaginamane
Lophius Biosciences GmbH
Woitach Joseph
LandOfFree
Method for identifying target epitopes of the T cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for identifying target epitopes of the T cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for identifying target epitopes of the T cell... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4215439