Method for identifying mutants and molecules

Details Method for identifying mutants and molecules Method for identifying mutants and molecules

1996-11-18

1998-07-14

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 800 2, 935 77, 935 78, C12P 1934, C12Q 168

Patent

active

057802360

ABSTRACT:
A method for breeding mutagenized mice that permits detection of genetic loci that can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the index phenotype. In the test generation, clusters of individuals are observed to deviate from the typical phenotype. The genetic material and molecules encoded thereby can be obtained using available methods.

REFERENCES:
patent: 5492808 (1996-02-01), de la Chapelle et al.
Moser et al. Science 247:322-324 (Jan. 19, 1990).
Moser et al. J. Cell. Biol. 116(6):1517-1526 (Mar. 1992).
Su et al., Science 256:668-670 (May 1, 1992).
Cancer Economics, Sep. 1996, pp. 1,2 and 7.
Dietrich, et al., "Genetic Identification of Mom-1, a Major Modifier Locus affecting Min-Induced Intestinal Neoplastia in the Mouse," Cell 75:631-639 (1993).
Friedrich, Glenn A., "Moving Beyond the Genome Projects," Nature Biotechnology 14:1234-1237 (1996).
Roush, Wade, "Biotech Finds a Growth Industry," Science 273:300-301 (1996).
Shedlovsky, et al., "Induction of Recessive Lethal Mutations in the T/t-H-2 Region of the Mouse Genome by a Ponit Mutagen," Genet. Res., Camb. 47:135-142 (1986).
Zhang, et al., "Positional Cloning of the Mouse Obese Gene and its Human Homologue," Nature 372:425-432 (1994).

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