Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-03-27
2007-03-27
Bunner, Bridget (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S375000, C544S247000, C560S003000
Reexamination Certificate
active
10121759
ABSTRACT:
The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Navexpression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.
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Tumilowicz et al.,
Brown Sean
Chaplan Sandra
Dubin Adrienne
Kaftan Edward
Bunner Bridget
Ortho-McNeil Pharmaceutical , Inc.
Woodcock & Washburn LLP
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