Method for identifying modulators of NA v ion channels

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S375000, C544S247000, C560S003000

Reexamination Certificate

active

10121759

ABSTRACT:
The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Navexpression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.

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