Method for identifying MLK inhibitors for treatment of...

Details Method for identifying MLK inhibitors for treatment of... Method for identifying MLK inhibitors for treatment of...

2007-07-27

2009-06-09

Allen, Marianne P (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S004000, C435S006120, C435S007100, C435S069100

Reexamination Certificate

active

07544479

ABSTRACT:
The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This invention also discloses methods for preventing neuronal cell death and treating neurological conditions that involve neuronal cell death, particularly neurodegenerative diseases characterized by glutamine or kainate mediated toxicity, such as Huntington's disease and Alzheimer's disease.

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Tibbles et al., The EMBO Journal, 15(24):7026-7035, 1996.
Yardin et al., Neuroreport, 9(9):2077-80, 1998.

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