Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-04-18
2006-04-18
Murphy, Joseph (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S325000, C530S350000, C530S351000, C530S387900
Reexamination Certificate
active
07029862
ABSTRACT:
The invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.
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Marchese, A. et al., “Cloning and Chromodomal Mapping of Three Novel Genes, GPR9, GPR10, and GPR14. Encoding Receptors Related to Interleukin 8, Neuropeptide Y, and Somatostatin Receptors,”Genomics,29:335-344 (1995).
Gen Bank Accession No. U32674, submitted by Marchese, A. et al., first released Oct. 2, 1995 according to personnel at the National Center for Biotechnology Information.
Taub, D.D., et al., “Recombinant Human Interferon-inducible Protein 10 is a Chemoattractant for Human Monocytes and T Lymphocytes and Promotes T Cell Adhesion to Endorhelial Cells,”J. Exp. Med.,177:1809-1814 (1993).
Sarris, A.H., et al., “Human Interferon-inducible Protein 10: Expression and Purification of Recombinant Protein Demonstrate Inhibition of Early Human Hematopoietic Progenitors,”J. Exp. Med.,178:1127-1132 (1993).
Luster, A.D. and Leder, P., “IP-10, a -C-X-C- Chemokine, Elicits a Potent Thymus-dependent Antitumor Response In Vivo,”J. Exp. Med.,178:1057-1065 (1993).
Angiolillo. A.L., et al., “Human Interferon-inducible Protein 10 is a Potent Inhibitor of Angiogenesis In Vivo,”J. Exp. Med.,182:155-162 (1995).
Luster, A.D., et al., “The IP-10 Chemokine Binds to Specific Cell Surface Heparan Sulfate Site Shared with Platelet Factor 4 and Inhibits Endothelial Cell Proliferation, ”J. Exp. Med.,182:219-231 (1995).
Taub. D.D., et al., “α and β Chemokines Induce NK Cell Migration and Enhance NK-Medicated Cytolysis,”J. Immunol.,155:3877-3888 (1995).
Luster, A.D., et al., “γ-Interferon Transcriptionally Regulates an Early-Response Gene Containing Homology to Plateler Proteins, ”Nature,315:672-676 (1985).
Farber, J.
Loetscher Marcel
Moser Bernhard
Emch Gregory S.
Hamilton Brook Smith & Reynolds P.C.
Murphy Joseph
Theodor-Kocher Institute
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