Method for identifying inhibitors of cdc2 protein kinase from pn

Details Method for identifying inhibitors of cdc2 protein kinase from pn Method for identifying inhibitors of cdc2 protein kinase from pn

1997-06-13

1999-01-26

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435194, 435183, C12Q 100, G01N 3353, C12N 912, C12N 900

Patent

active

058637419

ABSTRACT:
A nucleic acid and corresponding polypeptide that aids in the regulation of the cell cycle in Pneumocystis carinii is described. Antibodies generated against a unique carboxyl-terminus region of the polypeptide have specific binding affinity for P. carinii Cdc2 polypeptide and are beneficial in diagnosing and monitoring P. carinii infection in patients. Expression of P. carinii Cdc2 polypeptide in cdc2-mutant yeast and other cdc2-mutant organisms provides a useful model for studying the life cycle of P. carinii and for identifying novel therapeutics.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
Thomas et al., "Identification of a Cell Division Cycle (cdc2) Homologue in Pneumocystis Carinii," J. Euk. Micro, vol. 43, No. 5 Sep.-Oct. 1996.
Thomas et al., "The Pneumocystic Carinii cdc2 Cell Division Cycle Homologue Exhibits Characteristics Protein Kinase Activity," Chest, 110:66S (1996).
Thomas et al., "Partial Cloning of the Pneumocystis Carinii Cell Division cycle (cdc2) Homologue Using Polymerase Chain Reaction," J. Invest. Med., 44:397A (1996).
Thomas et al., "Evidence for a Pneumocystis Carinii Cell Division Cycle (cdc2) Homologue," Am. J. Resp. Care Med., 153:A433 (1996).
J. Pines, "The cell cycle kinases," Seminars in Cancer Biology, 5:305-313 (1994).
Fleig et al., "Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation," Seminars in Cell Biology, 2:195-204 (1991).
Sambrook et al., Molecular Cloning, second edition, Cold Spring Harbor Laboratory, Plainview, NY (Sections 7.39-7.52) (1989).
Dayhoff, et al., "A Model of Evolutionary Change in Proteins," Atlas of Protein Sequencing and Structure, vol. 5, Suppl. 3, pp. 345-352 (1978).

Affiliated with

Also associated with

Rating

Method for identifying inhibitors of cdc2 protein kinase from pn does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for identifying inhibitors of cdc2 protein kinase from pn, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for identifying inhibitors of cdc2 protein kinase from pn will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1449549