Method for identifying inhibitors for apopain based upon the cry

Details Method for identifying inhibitors for apopain based upon the cry Method for identifying inhibitors for apopain based upon the cry

1997-02-13

1998-11-10

Weber, Jon P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435212, C12Q 137, C12N 948

Patent

active

058342281

ABSTRACT:
The apopain:Ac-DEVD-CHO complex has been crystallized and its structure determined by x-ray crystallography. Based upon this crystal structure of the complex, a method for identifying inhibitors of apopain is presented which comprises designing putative inhibitors having specific contacts with apopain, making the putative inhibitors, and testing the putative inhibitors for their ability to inhibit apopain.

REFERENCES:
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Rotonda et al. (1996) Nat. Struct. Biol., 3(7), "The Three-Dimensional Structure of Apopain/CPP32, a Key Mediator of Apoptosis" pp. 619-625.

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