Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-03-15
2005-03-15
Sisson, Bradley L. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100, C536S024310, C536S024330
Reexamination Certificate
active
06866999
ABSTRACT:
This invention relates to diagnostic methods based upon a particular genotype in the Tumor Necrosis Factor (TNFα) gene, more specifically, an adenine and guanine (“GA”) at the −308 site (or AA) rather than the GG at this locus. More specifically, this invention relates to a method for diagnosis of increased risk of death in patients with community-acquired pneumonia (CAP) and diagnosing pre-disposition or susceptibility to increased risk of death in patients who develop CAP, by screening for the presence of this polymorphism. The invention also relates to compositions for screening for the polymorphism and improved treatment choices for patients having the polymorphism of the present invention.The invention also relates to screening assays and therapeutic and prophylactic methods.
REFERENCES:
patent: 5200313 (1993-04-01), Carrico
patent: 6294339 (2001-09-01), Wunderink et al.
patent: 20020119455 (2002-08-01), Chan
patent: 0 200 362 (1986-03-01), None
patent: 0 201 184 (1986-03-01), None
Zhang et al., Bioinformatics, vol. 19, No. 1, 2003, pp. 14-21.*
Fine et al., “A Prediction Rule to Identify Low-Risk Patients with Community Acquired Pneumonia”, The New England Journal of Medicine 1997 336 (4):243-250.
Hirose et al., “The E-linked subregion of the major histocompatibility complex down-regulates autoimmunity in NZB X NZW F1mice”, Immunogenetics 1994 40:150-153.
Wilson et al., “An Allelic Polymorphism within the Human Tumor Necrosis Factor α Promoter Region Is Strongly Associated with HLA A1, B8, and DR3 Alleles”, J. Exp. Med. 1993 177:557-560.
Waterer Grant William
Wunderink Richard Glenn
Licata & Tyrrell P.C.
Sisson Bradley L.
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