Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-07-05
2011-07-05
Romeo, David S (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007500, C514S005900, C514S576000
Reexamination Certificate
active
07972798
ABSTRACT:
The present invention provides methods for detecting and measuring, in a sample from a subject, the plasma levels of endothelial cell antibodies to diagnose an increased risk of pathological complications, such as visual impairment, associated with diabetes.
REFERENCES:
Antibodies to endothelial cells. Lancet. Mar 16, 1991;337(8742):649-50.
Fillit et al. Association of autoimmunity to vascular heparan sulfate proteoglycan and vascular disease in the aged. Gerontology. 1993;39(4)177-82.
Jones et al. Vascular endothelial cell antibodies in diabetic patients. Association with diabetic retinopathy. Diabetes Care. Apr. 1992;15(4):552-5.
Petty et al. Diabetes is associated with a high incidence of endothelial-binding antibodies which do not correlate with retinopathy, von Willebrand factor, angiotensin-converting enzyme or C-reactive protein. Diabetes Res. Jul. 1991;17(3):115-23.
Powers, A.C. “Diabetes Mellitus”, Chapter 323 in, Harrison's principles of internal medicine, 16th ed., editors, Dennis L. Kasper et al., New York : McGraw-Hill, c2005, pp. 2152, 2161.
Alder Janet
Pan Zui
Thakker-Varia Smita
Zimering Mark B.
Adriano & Associates
Romeo David S
The United States of America as represented by the Department of
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