Method for identifying compounds which affect ionotropic...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C435S007210

Reexamination Certificate

active

10299957

ABSTRACT:
A method is provided for identifying a compound which affects the formation of AMPA receptors into aggregates. The method also provides for a compound, for example, a long pentraxin polypeptide or fragment thereof, having a pentraxin binding domain and affecting AMPA receptor aggregation. The method provided herein affects AMPA receptor aggregation of GluR1, GluR2 and GluR3 receptor subunits.

REFERENCES:
Garlanda et al. Annu. Rev. Immunol. 2005. 23:337-66.
Goodman et al. Cytokine & Growth Factor Rev. 1996. 7: 191-202.
Bottazzi et al. J. Biol. Chem. 1997. 272:32817-32823.
Scott et al. Nature Genetics, 1999, 21:440-443.
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions.” Science, vol. 247: 1306-10, Mar. 1990.
Ngo et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox.” The Protein Folding Problem and Tertiary Structure Prediction: 491-495, 1994.
Frommel et al., “An Estimate on the Effect of Point Mutation and Natural Selection on the Rate of Amino Acid Replacement in Proteins.” J. Mo. Evol., vol. 21: 233-257, 1985.
O'Brien, et al., “Synaptic Clustering of AMPA Receptors by the Extracellular Immediate-Early Gene Product Narp,”Neuron23 (2):309-323 (1999).
Tsui, et al., “Narp, a Novel Member of the Pentraxin Family of Proteins that is Synthesized, Secreted and Active as a Monomeric Molecule,”Society of Neuroscience Abstracts. 26 Annual Meeting (Washington, DC) 22:(Part I of 3):p. 299, Abstract No. 125 (1996).
Tsui, et al., “Narp, a Novel Member of the Pentraxin Family, Promotes Neurite Outgrowth and Is Dynamically Regulated by Neuronal Activity,”The Journal of Neuroscience, 16 (8):2463-2478 (1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for identifying compounds which affect ionotropic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for identifying compounds which affect ionotropic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for identifying compounds which affect ionotropic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3787037

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.