Method for identifying compounds having increased activity for t

Details Method for identifying compounds having increased activity for t Method for identifying compounds having increased activity for t

1995-03-31

1998-09-15

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514432, 514557, 514563, 514569, A61K 3107, A61K 3119, A61K 3138

Patent

active

058079009

ABSTRACT:
A method of inducing the repair of photodamage to human skin comprising topically administering a composition containing a multi-selective retinoid which transactivates both of the human RAR-.alpha. and RAR-.gamma. receptors in combination with a compound which inhibits the binding of said multi-selective compound to the human RAR-.alpha. receptor is disclosed.

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Weiss, et al, Topical Tretinoin Improves Photodamage Skin, Jama, vol. 259, No. 4 pp. 527-532 (1988).
Kligman, et al, Topical Retinoic Acid Enhances The Repair Of Ultraviolet Damaged Dermal Connective Tissue, Connective Tissue Research, vol. 12 pp. 139-150 (1984).
Weinstein, et al, Topical Tretinoin for Treatment of Photodamage Skin, Arch Dermatol, vol. 127, pp. 659-665 (1991).
Armstrong, et al, Clinical Panel Assessment Of Photodamage Skin Treated With Isotretinoin Using Photographs, Arch Dermatol, vol. 128, pp. 352-356 (1992).
Apfel, et al, A Retinoic Acid receptor .alpha. antagonist selectively counteracts retinoic acid effects, Proc. Natl. Acad. Sci. vol. 89, pp. 7129-7133 (1992).
Bernard, et al, Identification Of Synthetic Retinoids With Selectivity For Human Nuclear Retinoic Acit Receptor .gamma., Biochemical and Biophysical Research Communications, vol. 186, No. 2, pp. 977-983 (1992).
K. Eckhardt et al., Toxicology Letters, 70:299-308 (1994).

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